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Persistent vomiting, severe nausea that prevents eating, diarrhea lasting more than a week, or any symptom that significantly impacts your daily functioning requires medical attention and likely a dose adjustment

6.6.4 Glucocorticoids The presence of glucocorticoid receptors in endothelial and inflammatory cells (240243), as well as increased concentrations of circulating glucocorticoids at the onset of inflammation downregulating inflammatory responses, is proof that glucocorticoids are modulators of inflammatory responses (243, 277)

However, anecdotal reports from online forums cited in a 2025 systematic review included anxiety and panic attacks, depression and anhedonia, insomnia, heart palpitations, fatigue and weakness, and loss of appetite

Common symptoms include persistent fatigue, a weakened immune system leading to frequent illness, and skin issues

Enhanced paracrine action of FGF21 in stromal cells delays thymic aging